This column reviews the following psychiatric issues in SCD, with particular focus on recent research: first, depression and anxiety resulting from living with a chronic stigmatizing disease associated with chronic pain, unpredictable painful crises, multiple serious complications, poor health-related quality of life (HRQOL), and high mortality; second, problems of pain management, frequent undertreatment, and potential for substance abuse and addiction; third, coping styles; fourth, alcohol abuse; and last, central nervous system (CNS) injury and resulting cognitive dysfunction from strokes, primarily during childhood. SCD is an autosomal recessive genetic disorder of hemoglobin (Hb) structure and the most common of the hemoglobinopathies. In the United States, this happens in approximately one in 375 African-American births. Other genetic variants producing SCD include two forms of sickle cell-beta thalassemia (Sβ° and Sβ ) and sickle cell-hemoglobin C (SC).
This story is about his youngest daughter, Aryiana or Ary as he affectionately calls her.This happens when only one parent passes on the sickle cell gene. Morbidity associated with sickle cell disease in pregnancy.There are several forms of the disease: The most common and the most serious is sickle cell anemia. American Journal of Obstetrics & Gynecology 199(2):125.e1-125.e5.“She said she didn’t have it.” What is sickle cell disease?It is a group of inherited blood disorders that causes red blood cells to be deformed (sickle shaped — see photo below) and inflexible. Fred presented her with the same question and she responded the same way. I wouldn’t have married you if I had known our kids could have this disease.” Yvette stayed on the phone and we chatted more about Ary. Ary is 10 years old, but the memory of that day was still fresh enough to make her emotional.(This shape also resembles the curved blade of a farmer's sickle.) These abnormally shaped cells can get stuck in blood vessels, causing severe pain and other complications.